Currently, FLAC is the only lossless codec with hardware support, although it is still a little limited.
Even if you are picky about quality and space is not a problem, I'd suggest you to contemplate the possibility of using a lossy codec. Even MP3 (currently unmatched at hardware/software support) at the recommended settings (LAME alt-preset standard, xtreme or insane) is transparent to the great majority of people, unless they are well-trained in artifact detecting or have a combination of good ears and equipment. AAC and Vorbis, while they can't still match MP3's hardware support, have a respectable and growing variety of hardware supporting them (notably the iPod for AAC); and are more advanced codecs than MP3.
I would suggest you to perform an ABX test (
what is that?) with these lossy formats and the samples of your collection you consider to be the most complex and difficult. If you can't tell the difference at all, then maybe using lossy and enjoying of the extra space (or saved money) and variety of support is not a bad idea.
By the way, please use a more descriptive title for any subsequent threads you might post in the future.