okay... as far as i recall the TIFF image format is an open standard (could be wrong - i've not researched the matter).
i was rather chagrined today to find that when i tried to save my 16 bit tiffs that resulted from decoding some RAW camera files i had, LZW results in LARGER files than i started with when working with 16 bits. zip isn't good with this either, but rar is handier.
here's where my idea comes. i decided to save 1 channel of a 16 bit tiff to a headerless data file and open it up in cooledit. after attaining a decent looking file (i had to unfortunately keep colours under 128 to avoid offsetting fullscale to minus fullscale in cooledit, effectively giving me 15 bits instead of 16) i decided to save to FLAC at full compression.
i got a smaller file than RAR, and a very good ratio over my original file.
original tiff = 7572kB
lzw tiff = 7961kB (WTF?)
original in rar at maximum = 4391kB
FLAC compressed raw data (compression set to 8) = 4035kB
the speed was comparable (faster?) to the rar file, and the size was smaller.
so would it be possible for FLAC to be used in 16 bit TIFF compression? i don't know enough about the format, but this seems intriguing.