don't trust anyone, test them all & see ...
many people that will tell you that this codec/setting is the
best are just zealot newbies that don't have an overall view on patents/norms/efficiency/speed/potential/ABXing
actually lossy is a game: the first who find the mp3 successor win ...
those who don't wanna play bet on mp3/lossless so they can't lose ...
it seems those who bet on mpc some years ago already losed, many of them are turning to lossless due to this bad experience ...
those who bet on wma ... are insane because standards are made by audio pirates & most of these pirates hates microsoft ...
now you have MP4-OGG remaining ... & it's fifty-fifty actually Ogg is better in audio, MP4 is better in video ... some people consider mp4 safer because it's in the mpeg family ... some people consider ogg safer because it's free software ...
so to be short:
If you don't wanna play use lame APS or lossless
If you wanna play the game without reading the rulz use wma or mpc
If you wanna play the game after reading the rulz use mp4 160kbps or Vorbis Q5
I don't like that stupid game much but I have bet on Vorbis Q5, so wish me luck

the biggest thing to fear with vorbis is that it became the next mpc ... but with all the linux community behind him this is doubtfull ... the only thing that could prevent vorbis to be the next standard for me is a patent claim coming out from nowhere ... or AVC popularity maybe ... but not AAC alone ...