Are there any recommended settings? I've seen settings used for burnatonce.

You just need to make sure that you select a filesystem which won't truncate file/folder names and directory paths. Also you have the option of adding extra error correction data to the DVD+/-R's with e.g. dvdisaster. I personally always write my lossless WavPack images with embedded cuesheets and eaclogs to TY or MCC DVD+R's and i write them as an UDF filesystem. I would recommend ImgBurn for this, as it is an amazingly good and non-bloated freeware application. I don't personally use dvdisaster(or par2) myself, but i do reburn my DVD+R's once in a while - just to be safe. I would actually recommend you to use an external harddrive instead of using DVD+R's, and the only reason that i'm not using this approach instead, is only because i don't really can afford to buy one at this momment, as i'm personally un-employed, but indeed it would be the better and easier method to use IMHO.

Edit: I'm sorry - I have just reread your post and could now see that you said "Using Nero", so please ignore my "i would recommend ImgBurn"