QUOTE (PaJaRo @ Oct 12 2008, 17:30)

I'll try to buy the Whirlwind (better pay a little bit more than waste my money).
Two more questions:
1) Can my speakers be damaged if I still using them with that noise?
No, it's just like any other sound that your speakers reproduce. There is often some DC offset present with such noise, but since the vast majority of modern amplifiers are AC-coupled (i.e. they block DC on their inputs), even a large amount (hundreds of millivolts) of DC offset would be eliminated at the amplifier's input.
QUOTE
2) when should i use ground lift button?
Whenever you hear the noise.

The whole point of the isolation transformers is to achieve complete physical isolation between your laptop and the speakers (or the amplifier driving the speakers). Since you will have solid grounds on each side of the transformer (through the power supply of your laptop on the input, and the power supply of the amplifier/powered speakers on the output), the ground does not need to be carried through. About the only time you need to connect the input and output grounds is if you're isolating a microphone or guitar pickup, i.e. sources that don't have their own electrical ground.
Edit: One other thing...to get from your Edirol interface into the ISO-2, you'll need RCA-to-1/4" adapters, as I mentioned. However, the ISO-2 only has XLR outputs, so you'll need appropriate adapters to get from XLR to whatever the inputs of your amplifier are (although you mentioned balanced connections, so perhaps your amplifier/powered speakers are already capable of that?). Remember, if the inputs of your amplifier are unbalanced, you need to make sure the XLR-to-whatever adapters short the cold (-) leg (pin 3 on an XLR) to ground (pin 1 on an XLR).